Research Associate at Cardiff University

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Research Associate
Cardiff University
- Division of Infection and Immunity - Cancer Immunology, School of Medicine, College of Biomedical and Life Sciences
Location:
Cardiff
Salary:
£34,304 to £40,927 per annum (Grade 6)
Hours:
Full Time
Contract Type:
Fixed-Term/Contract
Placed On:
7th March 2022
Closes:
31st March 2022
Job Ref:
13726BR
This post is funded by Cancer Research UK and will work on a project entitled ‘Exploring the Relationship Between Antigen-Specific T Cells and the Tumour Microenvironment’.
We have evidence that the anti-tumour T cell response can, under certain circumstances, drive structural alterations to the tumour microenvironment (TME) which serve to amplify the immune response leading to tumour destruction. Our findings indicate that changes to the TME are widespread and are characterized by the development of specialised blood vessels named high endothelial venules (HEV), re-organization of lymphatic vessels and loss of extracellular matrix (ECM). Based on these data, we hypothesise that tumour rejection may be improved by equipping particular antigen-specific T cells with the ability to drive alterations in the TME.
We need an experienced molecular biologist to genetically modify a range of in vivo and human antigen-specific T cells already present within the lab. The individual will work with a team of cellular immunologists to test the ability of modified T cells to function in vitro and in vivo. For this purpose, a range of techniques including confocal microscopy, T cell-organoid co-culture systems and in vivo models will be used. The overall purpose of the work is to determine whether T cell-based immunotherapy can be enhanced by empowering adoptively transferred T cells with the ability to alter the TME. The lab is situated at the Henry Wellcome Building, Cardiff University, UK.
To find out more about the lab, please see ****This post is full time (35 hours per week), available immediately and fixed term until 31st March 2027.
Salary: £34,304 - £40,927 per annum (Grade 6)
Closing date: Thursday, 31 March 2022
Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.
Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds. We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age.  In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.
“Cardiff University is a signatory to the San Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions we will evaluate applicants on the quality of their research, not publication metrics or the identity of the journal in which the research is published. More information is available at: 
****We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
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