PhD studentship: Cold-Chain Stable Prote

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PhD studentship: Cold-Chain Stable Protein/Polymer Therapeutic Conjugates
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Qualification Type:
PhD
Location:
Coventry
Funding for:
UK Students
Funding amount:
fully funded project - fees and stipend paid at UKRI rates.
Hours:
Full Time
Placed On:
22nd February 2022
Closes:
22nd May 2022
Supervisor: Prof Matthew Gibson
By value, the largest segment of the pharmaceutical market is protein biologics, which includes antibody as well as gene therapies and vaccines. All of these face the major challenge of retaining function during transport necessitating a cold chain, which in many cases includes freezing. Most biologics cannot survive freeze-stress without cryoprotectants, and often have to be stored at e.g. -80 C (as seen for COVID vaccine) which creates health inequalities.
The aim of this PhD is to prepare and characterize therapeutic protein/polymer conjugates, where the polymers have the unique function to modulate ice growth, which has been shown to mitigate stress during protein cold storage (e.g. Materials Horizons, 2019, 6, 36).  This will involve the installation of unnatural amino acids into precise locations in the protein drugs, and the full characterization (sequencing) followed by site-specific polymer conjugation and full characterization of the conjugates (using chromatography and MS).
The project is highly multidisciplinary leveraging biochemistry, protein expression, polymer chemistry and crystallisation to help understand the function of next-generation protein pharmaceutics.
Cold-Chain Stable Protein/Polymer Therapeutic Conjugates (warwick.ac.uk)
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