PhD Studentship in Biomedical Sciences at University of Read

Profile

PhD Studentship in Biomedical Sciences
University of Reading
- School of Biological Sciences
Qualification Type:
PhD
Location:
Reading
Funding for:
UK Students
Funding amount:
Funding covers full tuition fees plus UKRI stipend. Funding covers full UK/Republic of Ireland tuition fees, plus UKRI stipend (£15,609 for 2021/22) per year.
Hours:
Full Time
Placed On:
21st February 2022
Closes:
31st March 2022
Reference:
GS22-001
Project title:
  Investigation of dopamine transporter dysfunction presenting with parkinsonian phenotypes using CRISPR-Cas engineered C. elegans and human iPSC models
Department/School:
School of Biological Sciences
Supervisors:  
Dr Eva Kevei, University of Reading ;
Prof Manju Kurian, Neurogenetics Group, UCL; Dr Serena Barral, Neurogenetics Group, UCL
Project Overview:   
Dopamine transporter deficiency syndrome is an autosomal recessive parkinsonian disorder caused by mutations in the human dopamine transporter DAT/SLC6A3. Recently, several missense variants have been identified in people presenting a wider spectrum of parkinsonian phenotypes with varying onset and severity of disease. However, the impact of these mutations on the molecular function of SLC6A3 and their organism wide consequences on dopaminergic signalling are currently unknown. To investigate SLC6A3-linked disease mechanisms, in the Kevei lab, we will establish in vivo models of DTDS by CRISPR-Cas engineering of novel disease variants into the endogenous C. elegans orthologue DAT-1. In humans, dopamine regulates a range of behavioural responses and motor control, most of which are well conserved throughout evolution. The student will validate the impact of dat-1 mutations on dopamine-controlled behaviours and motor function and monitor neurotoxin-induced degeneration of dopaminergic neurons in C. elegans. To validate their findings, the student will test the impact of a selected disease SLC6A3 variant in a midbrain dopaminergic neuron model of DTDS, that they will develop from induced pluripotent stem cells (iPSCs) obtained from people with DTDS in the Kurian lab. The student will assess the cellular mechanisms underpinning disease, by investigating SLC6A3 functionality, dopamine toxicity, neurodegeneration and inflammation in the mutant dopaminergic cells. This will be followed by treatment of the dopaminergic neuron and the C. elegans models with pharmacochaperones, which have been effective in rescuing SLC6A3 folding defects.
Further information on the project is available at:
****Eligibility: 
Applicants should hold or expect to gain a minimum of a 2:1 Bachelor Degree or equivalent in in biosciences or a strongly related discipline.
Funding Details:
Start date: October 2022
This is a 4-year studentship fully funded for UK/Republic of Ireland candidates by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). International candidates are eligible to apply, however they would need to be able to fund the difference between UK/Republic of Ireland and International tuition fees. Funding covers full tuition fees plus UKRI stipend. Funding covers full UK/Republic of Ireland tuition fees, plus UKRI stipend (£15,609 for 2021/22) per year.
How to apply:  
To apply click at **** create your account and use the link sent by email to start the application process. During the application process please select the PhD in Biomedical Sciences PhD programme.
* Important notes*
1) Please quote the reference ‘GS22-001’ in the ‘
Scholarships applied for’
box which appears within the
Funding Section
of your on-line application.
2) When you are prompted by the online application system to upload a research proposal, please omit this step as the project is already defined.
Application Deadline:  31
st
March 2022
Further Enquiries:
Please note that, where a candidate is successful in being awarded funding, this will be confirmed via a formal studentship award letter; this will be provided separately from any Offer of Admission and will be subject to standard checks for eligibility and other criteria. 
For further details please contact Dr Eva Kevei: ****
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information
Type / Role:
Subject Area(s):
Location(s):
PhD tools
PhD Alert Created
Job Alert Created
Your PhD alert has been successfully created for this search.
Your job alert has been successfully created for this search.
Ok
Ok
PhD Alert Created
Job Alert Created
Your PhD alert has been successfully created for this search.
Your job alert has been successfully created for this search.
Manage your job alerts
Manage your job alerts
Account Verification Missing
In order to create multiple job alerts, you must first verify your email address to complete your account creation
Request verification email
Request verification email
jobs.ac.uk Account Required
In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account
Create Account
Create Account
Alert Creation Failed
Unfortunately, your account is currently blocked. Please login to unblock your account.
Login
Login
Email Address Blocked
We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.
Re-verify your email
Update your email
Re-verify your email
Update your email
Max Alerts Reached
A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert
Manage your job alerts
Manage your job alerts
Creation Failed
Unfortunately, your alert was not created at this time. Please try again.
Ok
Ok
Create PhD Alert
Create Job Alert
When you create this PhD alert we will email you a selection of PhDs matching your criteria.
When you create this job alert we will email you a selection of jobs matching your criteria.
Our Terms and Conditions
and Privacy Policy
apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice
Create PhD Alert
Create Job Alert
When you create this PhD alert we will email you a selection of PhDs matching your criteria.
When you create this job alert we will email you a selection of jobs matching your criteria.
Our Terms and Conditions
and Privacy Policy
apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice
I would like to receive email communication from jobs.ac.uk relating to Company News
I would like to receive email communication from jobs.ac.uk relating to Conferences, Meetings and Events
Save this job
Login to Save Job
Max Saved Jobs Reached
×
Max Saved Jobs Reached
A maximum of 500 Saved Jobs can be created against your account. Please remove an existing Saved Job in order to add a new Saved Job.
Manage Saved Jobs
×
Save Job
Please sign in or register for an account to save a job.
Sign In
Register
More PhDs from University of Reading
PhD Studentship in Agricultural, Environmental and Food Economics by Distance (full-time)
PhD Studentship in Food and Nutritional Sciences
PhD Studentship in Space weather and solar-terrestrial physics: Project title: Solar wind interaction with planets and minor planetary bodies
Show all PhDs for this organisation …
More PhDs like this
PhD Studentship: Mental Health in Rare Genetic Syndromes Associated with Intellectual Disability
PhD studentship: Cold-Chain Stable Protein/Polymer Therapeutic Conjugates
PhD Studentship: Exploring the co-benefits of re-carbonizing soils for food and planet
Cancer Research UK City of London Centre PhD training programme 2022
PhD Studentship - Investigating the Cellular Effects of External Environmental Stressors on Human Skin Circadian Rhythm
Join in and follow us
Copyright © jobs.ac.uk 1998 - 2022
Find a Job
Find PhDs
Career Advice
Jobs by Email
About Us
****
IE11 Trigger
Browser Upgrade Recommended
jobs.ac.uk has been optimised for the latest browsers. For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Company info

Sign Up Now - EducationCrossing.com