PhD Studentship: Ultrasonic microbubbles as an advanced therapy for drug delivery

Profile

PhD Studentship: Ultrasonic microbubbles as an advanced therapy for drug delivery in bone repair
**MEMBERS ONLY**SIGN UP NOW***.
Qualification Type:
PhD
Location:
Southampton
Funding for:
EU Students, International Students, Self-funded Students, UK Students
Funding amount:
For UK students, Tuition Fees and a stipend of £15,609 tax-free per annum for up to 3.5 years
Hours:
Full Time
Placed On:
23rd February 2022
Closes:
31st August 2022
Project title: Ultrasonic microbubbles as an advanced therapy for drug delivery in bone repair
Supervisory Team:
   Nicholas Evans (FEPS), Janos Kanczler (FOM), Simon Tilley (FOM and NHS) and Dario Carugo (UCL)
Project description
Bone fractures are a huge problem. A big part of this problem comes from non-union or delayed-union fractures, which affect about 5-10% of cases. These poorly healing bone fractures are devastating for the person affected, sometimes taking many years of major surgery and extensive rehabilitation. Despite this, there are very limited drugs available which are known to improve bone fracture healing.
We hypothesise that getting the right drug to the right place at the right time is an extremely important consideration in bone healing, and is part of the reason why current candidate drugs have failed.
To solve this problem, we are investigating ultrasound-responsive microbubbles as a way to deliver drugs locally in fracture healing. They can be injected in the blood, and stimulated with sound when they flow through a tissue of interest. Ultrasound-responsive microbubbles (MBs) have been used clinically since the 1990s as contrast agents for imaging.  Due to the fact that they are gas filled, microbubbles reflect significantly more ultrasound energy than surrounding fluid-filled tissues. This distinctive ‘echo’ is the reason why they can be detected when flowing through the blood vessels of ultrasound-imaged tissues. They are presently safely and widely used, including here in Southampton General Hospital, for imaging of patients.
However, when MBs are exposed to ultrasound, they ex-and and contract at specific resonance frequencies. This phenomenon is analogous to the vibrations that an opera singer might induce in a glass. The rapid oscillations can produce significant forces on structures in the immediate vicinity of MBs. Our collaborators have exploited these effects to increase the movement of weakly cell permeable molecules, e.g. proteins and nucleic acids, through cell membranes. Such technology is now under development for delivery of chemotherapeutic drugs or molecules to tumour sites. It remains unknown whether this method may be suitable for stimulating drug delivery in bone fracture.
During this PhD you will try and find an answer to this question. You will use a range of state-of-the-art techniques in acoustics, tissue culture and cellular imaging to measure and uptake of comounds, and molecular methods to determine their effect on target cells and tissues.
You will work in a vibrant, multidisciplinary team between the Medicine and Engineering departments at the **MEMBERS ONLY**SIGN UP NOW***., and in collaboration with the University of Oxford. You need to have at least a 2:1 or equivalent and you will have any of the natural sciences.
Entry Requirements
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).
Closing date
: 31 August 2022 for standard admissions, but later applications may be considered depending on the funds remaining in place.
Funding:
For UK students, Tuition Fees and a stipend of £15,609 tax-free per annum for up to 3.5 years.
How To Apply
Apply online: ****. Select programme type (Research), 2022/23, Faculty of Physical Sciences and Engineering, next page select “PhD Engineering & Environment (Full time)”. In Section 2 of the application form you should insert the name of the supervisor Nicholas Evans
Applications should include
Curriculum Vitae
Two reference letters
Degree Transcripts to date
For further information please contact: ****
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information
Type / Role:
Subject Area(s):
Location(s):
PhD tools
PhD Alert Created
Job Alert Created
Your PhD alert has been successfully created for this search.
Your job alert has been successfully created for this search.
Ok
Ok
PhD Alert Created
Job Alert Created
Your PhD alert has been successfully created for this search.
Your job alert has been successfully created for this search.
Manage your job alerts
Manage your job alerts
Account Verification Missing
In order to create multiple job alerts, you must first verify your email address to complete your account creation
Request verification email
Request verification email
jobs.ac.uk Account Required
In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account
Create Account
Create Account
Alert Creation Failed
Unfortunately, your account is currently blocked. Please login to unblock your account.
Login
Login
Email Address Blocked
We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.
Re-verify your email
Update your email
Re-verify your email
Update your email
Max Alerts Reached
A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert
Manage your job alerts
Manage your job alerts
Creation Failed
Unfortunately, your alert was not created at this time. Please try again.
Ok
Ok
Create PhD Alert
Create Job Alert
When you create this PhD alert we will email you a selection of PhDs matching your criteria.
When you create this job alert we will email you a selection of jobs matching your criteria.
Our Terms and Conditions
and Privacy Policy
apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice
Create PhD Alert
Create Job Alert
When you create this PhD alert we will email you a selection of PhDs matching your criteria.
When you create this job alert we will email you a selection of jobs matching your criteria.
Our Terms and Conditions
and Privacy Policy
apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice
I would like to receive email communication from jobs.ac.uk relating to Company News
I would like to receive email communication from jobs.ac.uk relating to Conferences, Meetings and Events
Save this job
Login to Save Job
Max Saved Jobs Reached
×
Max Saved Jobs Reached
A maximum of 500 Saved Jobs can be created against your account. Please remove an existing Saved Job in order to add a new Saved Job.
Manage Saved Jobs
×
Save Job
Please sign in or register for an account to save a job.
Sign In
Register
More PhDs from **MEMBERS ONLY**SIGN UP NOW***.
PhD Studentship: Experimental Aerodynamics and Environmental Flows
PhD: Enhancing Protein and Ligand Sampling in Molecular Simulations by Fully Adaptive Simulated Tempering (FAST)
PhD Studentship: Interpretable data-driven building energy analytics
PhD Studentship: Tribological mode of action of spherical silica in a tooth brushing contact
PhD Studentship: Cyclorotor aerodynamics for advanced aerial mobility
NIHR SPCR PhD Studentship
Show all PhDs for this organisation …
More PhDs like this
PhD studentship: A new era of cancer genomics: Utilising the new reference genome to explore sequence variation and transcription within centromeres in childhood cancer
Water Infrastructure and Resilience (WIRe) CDT PhD studentship: Resilience to climate change and its impact on dissolved manganese concentration in water reservoirs
PhD Studentship in Lipid-Based Conjugate Self-Assembly and Bioactivity Studies
Water Infrastructure and Resilience (WIRe) CDT PhD studentship: Quantifying and abating greenhouse gas emissions from large wastewater treatment plants
PhD: Enhancing Protein and Ligand Sampling in Molecular Simulations by Fully Adaptive Simulated Tempering (FAST)
Join in and follow us
Copyright © jobs.ac.uk 1998 - 2022
Find a Job
Find PhDs
Career Advice
Jobs by Email
About Us
****
IE11 Trigger
Browser Upgrade Recommended
jobs.ac.uk has been optimised for the latest browsers. For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Company info

Sign Up Now - EducationCrossing.com